LatchBio · San Francisco or Remote
Skills: Python
AI Biologist - Microscopy Latch builds rigorous scientific benchmarks (benchmarks.bio http://benchmarks.bio) for AI agents across biology. We work with frontier labs and pharma to measure whether agents can handle real biological workflows: the messy, multi-layer reasoning that matters in the field. We’re seeking an AI Biologist to join our Microscopy team, pushing what AI can achieve in biological imaging. About the Role. You will be the scientific authority on ground truth, testing whether agents can reason like an expert microscopist. AI agents today struggle to interrogate raw images, separate real biology from artifacts in acquisition, staining, and segmentation, and reach conclusions an expert would stand behind. Experts themselves disagree on roughly 1 in 6 images, so knowing where the evidence ends is part of the work. You will work with software engineers and scientists to build the tasks and datasets behind our benchmarks across cell biology, tissue, and disease. Your judgment will set the standard agent outputs are held to, including: Build the task - Define what expert reasoning looks like for an imaging question, and write gold-standard answers with the rationale an experienced microscopist or pathologist would defend - Design realistic scenarios across the imaging workflow: sample prep, staining, acquisition, preprocessing, segmentation, quantification, and interpretation - Curate image datasets across modalities: immunofluorescence, confocal and live-cell, electron microscopy, histology and histopathology, and high-content screening - Build analysis pipelines in Python, including deep-learning segmentation, that produce verifiable ground truth - Partner with software engineers to turn your judgment into new workflows Set the hard calls - Test whether agents distinguish true signal from artifact, such as bleed-through, uneven illumination, fixation damage, out-of-focus planes, or segmentation failure - Adjudicate ambiguous images: decide what the data…
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