LatchBio · San Francisco or Remote
AI Biologist - Proteomics Latch builds rigorous scientific benchmarks (benchmarks.bio http://benchmarks.bio) for AI agents across biology. We work with frontier labs and pharma to measure whether agents can handle real biological workflows: the messy, multi-layer reasoning that matters in the field. We’re seeking an AI Biologist to join our Proteomics team, pushing what AI can achieve across proteomics, lipidomics, and metabolomics. About the Role. You will be the scientific authority on ground truth, testing whether agents can reason like an expert mass spectrometrist. AI agents today struggle to interrogate raw mass spec data, separate real biological signal from artifacts of sample prep, instrument behavior, and processing, and reach conclusions an expert would stand behind. You will work with software engineers and scientists to build the tasks and datasets behind our proteomics benchmarks, and over time lipidomics and metabolomics. Your judgment will set the standard agent outputs are held to, including: Build the task - Define what expert reasoning looks like for a mass spec question, and write gold-standard answers with the rationale an experienced mass spectrometrist would defend - Design realistic scenarios across the workflow: sample prep, acquisition, identification, quantification, and biological interpretation - Curate mass spec datasets across proteomics, lipidomics, and metabolomics, alongside antibody-based and sequencing data where relevant - Partner with software engineers to turn your judgment into new workflows Set the hard calls - Test whether agents can tell true biological signal from batch effects, contamination, poor identifications, or processing artifacts - Adjudicate ambiguous results: decide what the data supports, what it doesn’t, and which experiment would settle the question Judge the agent - Interrogate agent reasoning step by step, and challenge conclusions that sound right but wouldn’t survive lab meeting or peer review - Pinpoint…
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