LatchBio · San Francisco or Remote
AI Biologist - Pathogen Countermeasures Latch builds rigorous scientific benchmarks (benchmarks.bio http://benchmarks.bio) for AI agents across biology. We work with frontier labs and pharma to measure whether agents can handle real biological workflows: the messy, multi-layer reasoning that matters in the field. We’re seeking an AI Biologist to join our Pathogen Countermeasures team, pushing what AI can achieve in vaccine, antibody, and antiviral development against respiratory viruses. About the Role. You will be the scientific authority on ground truth, testing whether agents can reason like an expert countermeasures scientist. The benchmark covers vaccines, therapeutic antibodies, and antivirals for influenza, RSV, and coronaviruses. AI agents today struggle to interpret raw neutralization, epitope, and drug-response data, to separate real escape or resistance from assay noise, and to make the advance-or-kill calls an expert would stand behind. You’ll work with scientists and engineers to build the tasks and datasets behind our benchmarks, and your judgment will set the standard agent outputs are held to. Build the task - Turn real countermeasure workflows into tasks with clear, gradable answers: antigen and immunogen comparison, epitope mapping, neutralization and cross-reactivity, antiviral susceptibility, and resistance interpretation - Write gold-standard answers from raw data, with tolerances that reflect real assay, replicate, and strain variability - Curate data: neutralization titers, binding and epitope maps, serology time courses, EC50 and dose-response curves, and viral sequences with resistance markers Set the hard calls - Test whether agents can tell real escape or resistance from artifact: a titer drop that’s really assay drift, a passenger mutation mistaken for a resistance marker, or a single fold-change not backed by sequence data - Test whether agents separate binding from neutralization, immunogenicity from protection, and lab resistance from…
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