natera · South San Francisco
Skills: React, Python, Java, AWS, Docker
Job Title: Principal Software Engineer Location: South San Francisco, CA preferred; Remote optional Job Type: Full-time About the Role We're seeking a Principal Software Engineer to join Natera's R&D team. We build the cloud infrastructure, workflow platforms, and data platforms that R&D uses to do its science - including a Kubernetes-based workflow execution platform, a custom R&D LIMS system, and a set of supporting tools that routinely handle production-scale workloads. This is a senior technical role. You'll own the full architecture, implementation, and delivery of large projects across our platform. You'll partner with the team lead on roadmap and tough technical calls, mentor mid-level engineers, and help the team find the right solution for the problem - not the most elaborate one. We're a small team (4 engineers + lead) with broad scope, and we're heavily AI-augmented: every engineer uses Claude Code / Cursor as a daily tool, and we build our own AI tooling (custom plugins, MCP servers, agents) to multiply ourselves. Responsibilities Architecture & Delivery: Own the design, implementation, and delivery of major initiatives across our platform. Take fuzzy problems through to shipped, working software used in production. Technical Leadership: Lead architecture and design reviews. Help the team find the right solution for the problem and avoid unnecessary complexity. Influence technical decisions across the team. Mentorship: Mentor mid-level engineers through code review, design docs, and pairing. Raise the engineering bar by example. AI-Native Development: Build and improve our AI-coding tooling alongside the rest of the team. Help us push the frontier of agent-driven software development inside the company. Cross-Functional Partnership: Work with bioinformaticians, scientists, and other R&D engineers to understand their needs and translate them into platform capabilities. Partner with the team lead on roadmap, prioritization, and tough technical calls. Requi…
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