elevatebio · Waltham, Massachusetts, United States
ElevateBio is a technology-driven company powering the industry forward by helping partners realize the potential of their therapies from design to commercialization. We have integrated a differentiated set of technologies, end-to-end services, and industry-leading manufacturing expertise to develop advanced therapies faster and more efficiently. The Role We are seeking a scientist to engineer and optimize gene editing proteins by combining machine learning and protein language models with hands-on laboratory research. This individual will design protein variants, build and test them, and use experimental results to guide subsequent engineering cycles. Working closely with computational and translational scientists, this role will advance gene editing systems with improved activity, specificity, and properties relevant to therapeutic development. Here’s What You’ll Do Carry out directed evolution campaigns to improve activity and specificity of gene editing proteins. Generate protein libraries and variants through molecular cloning, mutagenesis, and related engineering approaches. Design and engineer gene editing proteins using sequence and structural analysis, machine learning, and protein models. Develop and execute iterative cycles that connect computational predictions with experimental results. Develop and perform biochemical and cell-based assays to evaluate gene editing efficiency, specificity, and performance. Analyze experimental datasets to identify sequence–function relationships and prioritize subsequent designs. Collaborate with computational scientists to adapt and evaluate predictive models using experimental data. Partner with translational teams to assess engineered systems in relevant biological contexts. Communicate findings and recommendations clearly, maintain rigorous documentation, and contribute to technical reports, intellectual property, and publications. Requirements Ph.D. in scientific discipline and a at least 3 years of relevant experie…
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