lilasciences · San Francisco, CA USA
Your Impact at LILA Lila Sciences is seeking an ML Scientist I/II, Nucleic Acid Design to advance RNA and DNA sequence design. This scientist will develop models and design strategies for understanding and engineering nucleic acid sequences, including problems such as 3’ UTR optimization, 5’ UTR optimization, CDS optimization, and promoter / enhancer design. You’ll work at the intersection of machine learning, sequence modeling, experimental design, and platform development. The work spans both applied design campaigns and building next-generation models that improve how Lila generates, evaluates, and learns from nucleic acid sequence-function data. The ideal candidate brings strong ML judgment, curiosity about biological mechanisms, and enthusiasm for areas such as regulatory genomics, RNA biology, and sequence-to-function modeling. You’ll collaborate with experimental scientists, ML researchers, and platform teams to build models that connect nucleic acid sequence design to biological function and make these capabilities usable across Lila’s autonomous science platform. What You'll Be Building Build ML models for RNA and DNA sequence design across regulatory and coding sequence contexts. Develop methods spanning de novo generation, sequence property prediction, diverse set selection for experimental validation, and active learning strategies. Deeply investigate the biological mechanisms of designed sequences and propose hypotheses about why they succeed or fail. Turn these insights into better models and future design principles. Partner with experimental scientists to propose informative assays, validation strategies, and learning loops. Collaborate with ML scientists and engineers across Lila to integrate nucleic acid design models into …truncated… ence™ to solve humankind's greatest challenges. We believe science is the most inspiring frontier for AI. Rather than hard-coding expert knowledge into tools, LILA builds systems that can learn for themselves. LILA co…
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